To add some additional details from my perspective using vocabulary from Episode 54 of the Lucretius podcast:
1) I believe the "pleasure" pill / machine would prevent the senses from being reliable, therefore, there would be no way to make choices based on reliable information.
2) Epicurus made repeated observations on the profligate life leading reliably to more pain than pleasure; therefore, that lifestyle is to be "censured" and not recommended if one wants to achieve the goal of leading a pleasurable, happy, blessed life.