Great podcast! It is often suggested that we could think of the senses as "honest witnesses" of the outside world and our brain as the judge sitting inside the courtroom. Sceptics do not trust the witnesses, Epicureans do trust the witnesses. An Epicurean understands that the witnesses (i.e. the senses) honestly report to him what they experienced, but what they experienced may not totally correspond to what actually happened. The larger number of (honest) witnesses the Epicurean judge has, the more accurate his impression of reality will be.
If you think the honest witnesses are liars you will have no ability to find out the truth, if you think the honest witnesses are completely accurate you will have a false impression of the truth -- if you understand the witnesses are honest, but flawed, you can increase your accuracy by generalizing the testimony of the witnesses.