I'd think you'd want to go down the path of oil and water.
While oil and water don't mix, i doubt it is immediately clear that there is an obvious context in which those are the only two alternatives. Even if you're talking salad dressing there's probably spices and other things that i as a non-foodie don't even know about that people would try to include in the mix.
The best illustrations will have to combine both the points that (1) the two don't mix and (2) these two are the only two possibilities.
