Also don't forget the inherent ridiculousness of trying to reason with someone who rejects evidence-based reasoning. They are speaking nonsense and once they start down that road Lucretius says the ultimate response is not to engage with them further:
Against him then I will refrain from joining issue, who plants himself with his head in the place of his feet.
In both the question of knowledge and of determinism you can point out to the other person that their position is self-contradictory, but ultimately in most cases they won't care about self-contradiction since they don't care about evidence.