PD25. "If on each occasion, instead of referring your actions to the end of nature, you turn to some other, nearer, standard, when you are making a choice or an avoidance, your actions will not be consistent with your principles."
Here is my interpretation:
If on each occassion, instead of referring your actions to the natural pursuit of a life of happiness (as guided by pleasure and pain) if you turn too quickly to a simplistic standard such as skepticism (suspension of Judgment (Epoché)), when you are making a choice or an avoidance, your actions will not be consistent with achieving the best life.
and Bryan