I suppose one of the main difficulties initially, is how we can reconcile Epicurus' physics with modern physics? How far are we able to poeticize the teachings to fit in with our modern science? I'm aware how prescient Epicurus' views were and would like the opinion of more classical minded epicureans.
One principle of the teaching of Epicurus is the notion of coherence between multiple explanations. So, regardless of the true identity of Dark Matter and Dark Energy, regardless of the physics that occurs behind an event horizon or within a singularity ... whatever we determine to be the case after this period of evaluation and experimentation, we know that the results will still have to be coherent with the observed behavior of particles.
Ultimately, the concepts that got us to the moon are the same concepts that corresponds with Epicurean atomism. Epicurean physics does not conflict with contemporary physics as much as it has gaps and limitations. For example, Epicurus did not conceptualize the idea of spacetime, but there is nothing in his teachings that directly contradict spacetime. It is an extension, rather than a revision, as is the case with other philosophies.