The following article "Crying Out In Despair" came up in my google news feed, and I think it makes a point worth noting: the ultimate end of the "Tranquilism" approach to understanding Epicurus is absurdity.
The writer cites Catherine Wilson as advocating "organizing your sock drawer" as an example of finding meaning in life. Is this an unfair criticism of Wilson's position? I don't really think so, because this kind of "meaningfulness" is indeed what she seems to end up advocating, because she does not consistently and forthrightly advocate "pleasure" as the goal.
I haven't finished reading Wilson's book (and for this very reason - that I don't find many of her articulation of Epicurus' position on pleasure to be persuasive). Yet from the parts I have read I also think ironically that she is indeed on of the better Epicurean book-writers out there today, in that she does not fall into this tranqulisim trap as far as do many others.
But when people are out there advocating inanities like "Christ is the antidote to depressing diagnoses," the response that is called for is not "tranquilism" and its logical conclusion of lowering your goals in life to the level of sock-drawer-organizing. This is biting criticism, and it is valid against the "tranquilist" position -- which a thorough reading of the texts establishes is *not* what Epicurus advocated.